Speed & productivity - hardware and software solutions working in harmony to transform cellular workflows
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High sensitivity for efficient imaging of a range of samples from dim to bright assays
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High resolution imaging for better segmentation and quantification of fine sub-cellular structures
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Image restoration providing confocal-like image quality - advanced deconvolution options in 2D/3D acquisition modes greatly increase image accuracy in the lateral and axial dimensions
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Rapid scanning of large areas and improved software functions facilitate efficient detection of rare events
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Automated filter, polychroic & objective changing for speed and convenience
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Environmental control options and optimized hardware/software solutions enable a wide range of live cell studies with unstained or fluorescently labeled samples
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Greatly enhanced functionality for slide imaging enables analysis of pathology samples, tissue arrays, cellular colonies and small organisms
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Precision hardware and novel software solutions for 3D sectioning of thick samples such as spheroids or small organisms
Key functions for screening & research applications
Screening Applications A combination of proprietary optics, a choice of large or standard chip camera and fast hardware and software autofocus delivers accurate, high-speed imaging for screening applications. A bright light source reduces exposure times to further maximize speed without compromising image quality and cell health while the rapid image restoration options allow confocal-like images to be obtained. System components have been subjected to rigorous accelerated lifetime testing using GE's six sigma performance guidelines to ensure reliability.
Key function
System feature
Applications
Speed
• Bright optics with powerful light source • Fast hardware autofocus • Fast on-line cell count function • Rapid slide imaging • Automated filter, polychroic & objective changing • Large camera
• Bright optics with powerful light source • High-performance CCD camera • Range of objectives to suit sensitivity requirements of varied applications • Rapid image resoration options - higher contrast & improved resolution even with dim samples • Z-axis projection & image restoration combine to provide virtually extended depth of field for high magnifications
• Phenotypic profiling in screens requiring resolution of subcellular features • Rapid detection of low abundance probes & weak fluorescent sensors
Reliability
• Robust design & construction • Stage accuracy & repeatability • Rapid hardware & software autofocus ensure desired plane of interest is always in focus • On-line cell counting to rapidly secure statistically reliable data collection • Large CCD camera maximizes data collection for statistically robust results
• Demanding screening applications with long run-times • Shared facilities meeting the demands of multiple users or screening programs
Research Applications A variety of innovative imaging features and a wide range of objectives (2× to 100×) gives exceptional flexibility for research use. The manual microscope mode allows you to work with images at full size and resolution, to zoom in and out and to manually adjust settings (e.g., filters, objectives, and z-height), and assess effects in real time.
Key function
System feature
Applications
Resolution & sensitivity
• High NA/high magnification objectives provide thin optical section and maximum resolution in lateral & axial dimensions • Bright optics with powerful light source to detect low abundance probes & weak fluorescent sensors • Rapid image resoration options - higher contrast & improved resolution even with dim samples • Z-axis projection & image restoration combine to provide virtually extended depth of field for high magnifications
• Phenotypic characterization of test compounds • Target identification • Protein localization • Functional studies • Antibody characterization
Live cell assays
• Variable temperature control (up to 42°C) • Environmental control module • 3 transmitted light modes • Accurate xy staging - better cell tracking • Hardware optimized for optical performance - reduced exposure times • Cell tracking software • Fast hardware autofocus
• Whole well imaging • Large chip CCD camera • 2x and 4x objectives • Preview Scan - rapid location of region of interest • Image overlap for stitching
• Accurate Z-staging • Quantitatively accurate 3D stacks with confocal-like image quality • Image restoration options for maximum resolution in lateral & axial dimensions
• Spheroids • Tissue sections • Small organisms (zebrafish, C. elegans, Xenopous oocytes etc) • Stacks suitable for 3D volume rendering and reconstruction of organelles, tissues etc
Slide imaging
• New intuitive graphical user interface • PreView Scan mode - rapid location of region of interest • Smart software autofocus algorithm for accuracy & exceptional speed • Automated objective changing • Image stitching
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