Bioinformatics is playing an increasing role for identifying and predicting the antigenic sites (epitopes) of pathogens which are the regions relevant to vaccine design. New sequence-based and structure-based prediction tools may help the future design of synthetic peptide vaccines.
Systems biology and vaccines (Day 2)
System biology and mathematic modeling to vaccine development will be discussed. The immune system involves the dynamic interplay of a large number of tissues, cells and molecules and this complexity makes the study of protective immune responses particularly apt to a system biology approach.
Uses of optical biosensors in vaccine development: from research to QC (Day 3)
Optical biosensor applications in vaccine development and QC will be the focus of the third day. Biosensors make it possible to measure the concentration of biologically active vaccine antigens at all stages of vaccine production and have many applications for the quality control of vaccines. They also give information on the binding kinetics of the antibodies produced during vaccination protocols, a parameter which has predictive value for vaccine efficacy. Surrogate assays able to reduce the number of experimental animals needed for vaccine evaluation will also be discussed.
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