A. Näslund, H. Björkelund, J. Stenberg, K. Andersson and G. Franklin
NATURE METHODS APPLICATION NOTES : 14-6 (2006)
A publication describing how inexperienced operators were able to screen 30,000 drug-target interactions in a matter of a few weeks using Biacore A100. The parallel processing capabilities of the system were employed to simultaneously screen the drug compounds against panels of serum albumins from several species.
Dr Walter Huber from Hoffman La-Roche describes a new approach to drug compound screening, combining structrural information with label-free biophysical analysis. Examples are provided to demonstrate how this approach can provide an efficient alternative to traditional high-throughput screening.
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