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Available below as recording (originally broadcasted on May 3, 2011)Please join us for a webinar presenting the use of Surface Plasmon Resonance technology for interaction studies with immobilized membrane proteins. Robert Karlsson will present real life examples on how BiacoreTM systems can used for the study of protein and small molecule interactions with immobilized membrane proteins. We look forward to seeing you online!
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Presented by:
Robert Karlsson
Director Scientific Support
GE Healthcare Life Sciences Mr. Robert Karlsson is one of the founders of Biacore platform technologies with special interest in assay development, methodology and data analysis. He is currently heading the scientific support team for label free technologies. He is a frequent lecturer both at conferences and at pharma/biotech and academic sites worldwide. |
Webinar recordingTo download or view the file below, please enter your login details. If you do not have a Biacore website account yet, you can sign up here.
Please note that in order to view the recording, you must install the Webex player, which is available free of charge here. The recording can then be viewed directly, or downloaded to your computer. |
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Studies of membrane protein interactions: challenges, possibilities and success stories (8.5 MB)
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Abstract
Membrane proteins are estimated to constitute close to 25% of the human proteome. They are key regulators of communication, signaling and transport and very important as drug targets. Studies of intact membrane proteins remain challenging for many techniques primarily due to solubilization and activity issues. Using Surface Plasmon Resonance (SPR) different approaches have been adopted for interaction studies using immobilized membrane proteins. These include utilization of soluble protein domains, stabilization of membrane proteins into a membrane like environment and direct use of solubilized membrane proteins. Progress both in terms of expression of membrane proteins and in improved sensitivity of SPR systems has recently made it possible to directly characterize the binding of drug like substances to immobilized membrane proteins. In this presentation, examples demonstrating both protein and small molecule binding to immobilized membrane proteins will be discussed and the presentation aims to review this exciting application segment.
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