Using label-free interaction analysis in compound characterization

A brief presentation to explain the principles and general value of using drug-target binding kinetic data during drug discovery and development.

Examples of information-rich, label-free characterization of compounds in drug discovery applications downstream of screening, such as hit-to-lead verification and lead optmization. Multiple assay types are covered, including analysis of binding kinetics, kinetic SAR, thermodynamics, binding site studies and early in vitro ADME. Note that some slides relating to the use of kinetics and ADME applications are also shown in the other, specialized presentations on these subjects that you will also find on this page.

Examples of how label-free interaction analysis can be implemented in early in vitro ADME studies to provide useful information for improved compound selection. Includes examples of plasma protein and liposome binding assays, as well as combined compound profiling.