To study an interaction, one of the interaction partners is immobilized onto the sensor surface of a Biacore sensor chip. Immobilization occurs by direct coupling to the surface or via a suitable molecule already coupled to the surface.
A range of sensor chips ensures that the most suitable sensor surface can be chosen according to the nature of the molecule to be coupled and the requirements for the analysis.
All Sensor Chips can be found in the online Product Center, where logged-in users can also see prices in local currency and create their own product lists.
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Recommendations in this table are based on the experience of scientists who have studied thousands of different protein interactions since the first Biacore system was introduced. Note, Flexchip chips are not included in this table. More information.
Protein interactions are monitored by injecting samples over the prepared sensor surface. Where appropriate, the sensor surface may be regenerated between injections by selective dissociation of the interaction partners. Regeneration solutions ensure complete dissociation, without affecting the binding characteristics of the immobilized partner.
The surface concentration of the immobilized interaction partner may need to be varied according to the type of analysis. In general, concentration and specificity assays require a high surface concentration, while lower concentrations are preferable for kinetic analysis.
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