Amersham Radiolabeling Service offers numerous labeling methods, from simple techniques such as tritiated water exchange to carbon-14 core labelling of a molecule. When choosing a radiolabel there are many aspects to consider, including the properties of the radionuclide and its performance in your experimental conditions. Specific activity and radiochemical stability considerations are outlined below.
We are happy to advise you on labeling options for your molecule.
Selection of radioisotope - specific activity & radiochemical stability considerations: • Higher specific activities are required when the chemical concentration of the tracer is low. • Stability is both a function of the molecule, the isotope and the position of labeling. • In general C-14 labeled compounds are more stable than their tritiated counterparts
Types of radioisotope labels
Our dedicated custom labeling experts provide GE Healthcare with a clear lead in expertise and experience in labeling:
Carbon-14 This is the isotope of choice for labeled products in most pharmacokinetic and agrochemical studies. It allows core labeling, rather than peripheral labeling of the molecule of interest, thus ensuring integrity of the label during your ADME investigation.
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