The gold standard for HTS Scintillation proximity assay (SPA) is a homogeneous, versatile assay technology for the rapid and sensitive analysis of a wide range of biological processes. The assay format requires no separation step and is amenable to automation, making it particularly suited to high-throughput screening applications.
SPA is a well-established technology, supported by more than 10 years of application data generated both independently and by scientists at Amersham Biosciences (now part of GE Healthcare). SPA is cited in over 500 literature references - click here.
SPA is widely recognized as the "gold standard" for radiometric high-throughput screening. Assays using either SPA Scintillation Beads or SPA Imaging Beads can be read on scintillation counters and CCD imagers respectively. Applications include receptor-ligand binding assays, enzyme assays, radioimmunoassays, and molecular interaction assays.
Key benefits
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Homogeneous: No separation or washing steps required - simply mix and measure
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Versatile: A range of bead coatings for a wide variety of targets
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Reduced assay costs: Eliminates requirement for filters and scintillation cocktails
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Reduced disposal costs: No radioactive liquid waste from filtration steps
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Improved safety: Streamlined assays mean less handling
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Precise: Absence of separation steps reduces potential errors
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Convenient: Beads are pre-coated for optimization of quantity per assay
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Automatable: compatible with 96-, 384-, and 1536-well formats
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Compatible with scintillation counters or CCD imagers
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